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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 877809Generated: October 29, 2026

Benzyl 4-amino-3,3-dimethylpyrrolidine-1-carboxylate → (S)-benzyl 4-(6-bromo-3-carbamoylpyrrolo[1,2-b]pyridazin-4-ylamino)-3,3-dimethylpyrrolidine-1-carboxylate

https://huagongshe.com/reaction/877809

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzyl 4-amino-3,3-dimethylpyrrolidine-1-carboxylateHCID 66936024—
Reactant6-Bromo-4-chloropyrrolo[1,2-b]pyridazine-3-carboxamideHCID 68291192—
Product(S)-benzyl 4-(6-bromo-3-carbamoylpyrrolo[1,2-b]pyridazin-4-ylamino)-3,3-dimethylpyrrolidine-1-carboxylateHCID 86707905—

Reaction Steps

According to the procedure described for Step 1 of Example 294, the title compound was prepared by coupling enantiopure Intermediate 11 with Intermediate 2.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08987268B2
Source datasetuspto-grants-2015_03
ORD IDord-76ffdfb351144602bd3bc927f9f8b5e2
Source noteuspto-grants-2015_03