Diisopropylethylamine → 6-Bromo-4-((1-(1-cyanocyclopropanecarbonyl)-4,4-dimethylpyrrolidin-3-yl)amino)pyrrolo[1,2-b]pyridazine-3-carboxamide

Participants

Reaction Steps

A solution of (+/−)-6-bromo-4-((4,4-dimethylpyrrolidin-3-yl)amino)pyrrolo[1,2-b]pyridazine-3-carboxamide hydroiodide (50 mg, 0.104 mmol) in DMF (0.3 mL), was added 1-cyanocyclopropanecarboxylic acid (13.9 mg, 0.13 mmol), BOP (55.4 mg, 0.13 mmol), DIPEA (0.046 mL, 0.26 mmol). The mixture was stirred at rt for 3 h, quenched with water then filtered. The solid was rinsed with water, dried under vacuum to give 6-bromo-4-((1-(1-cyanocyclopropanecarbonyl)-4,4-dimethylpyrrolidin-3-yl)amino)pyrrolo[1,2-b]pyridazine-3-carboxamide (36 mg, 78% yield) was obtained as a brown solid. MS (ES+) m/z: 444.1, 445.2 (M+H).

Provenance & Evidence