1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → (+/-)-4-(4,4-dimethyl-1-(methylsulfonyl)pyrrolidin-3-ylamino)-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	1-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole	HCID 2773987	—
Reactant	(+/-)-6-Bromo-4-((4,4-dimethyl-1-(methylsulfonyl)pyrrolidin-3-yl)amino)pyrrolo[1,2-b]pyridazine-3-carboxamide	HCID 68350406	—
Product	(+/-)-4-(4,4-dimethyl-1-(methylsulfonyl)pyrrolidin-3-ylamino)-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[1,2-b]pyridazine-3-carboxamide	HCID 68350506	—

Reaction Steps

The title compound was prepared according to the procedure described for Example 297 by Suzuki coupling with (+/−)-6-bromo-4-(4,4-dimethyl-1-(methylsulfonyl)pyrrolidin-3-ylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide (from Step 1 of Example 297) with 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08987268B2
Source dataset	uspto-grants-2015_03
ORD ID	ord-2330641d30c843d989774ba220b2aea0
Source note	uspto-grants-2015_03