Trimethylsilyl iodide → HCID 68291912, compound

Participants

Reaction Steps

Iodotrimethylsilane (0.134 mL, 0.938 mmol) was added dropwise to a solution of (3S,4R)-benzyl 4-((6-bromo-3-carbamoylpyrrolo[1,2-b]pyridazin-4-yl)amino)-3-fluoro-3-methylpyrrolidine-1-carboxylate (115 mg, 0.235 mmol) in acetonitrile (3 mL). After 1 h at room temperature, the mixture was quenched with methanol (1 mL) and concentrated in vacuo. The solid residue was triturated with diethyl ether (3 mL) and filtered. The filter cake was rinsed with diethyl ether and dried under vacuum to give crude 6-bromo-4-(((3R,4S)-4-fluoro-4-methylpyrrolidin-3-yl)amino)pyrrolo[1,2-b]pyridazine-3-carboxamide hydroiodide (120 mg), which was used in the next step without further purification. MS (ES+) m/z: 356.0 (M+H).

Provenance & Evidence