Benzoyl Peroxide → 2-(Bromomethyl)-3,5,6-trimethylpyrazine

Participants

Reaction Steps

More preferably, dissolving dehydrated tetramethylpyrazine into an organic solvent, preferably CCl4, and adding NBS at a molar ratio of tetramethylpyrazine to NBS=1:0.7, adding a small amount of benzoylperoxide as the radical initiator, reacting with the illumination of an incandescent lamp and reacting for 10-12 h under reflux, then cooling and condensing the reaction liquid, and sucking away the excess tetramethylpyrazine under reduced pressure in 60-70° C. water bath, the residue being kept in a fridge for standing and thus 2-bromomethyl-3,5,6-trimethylpyrazine being obtained as a pale-red half-oily substance.

Provenance & Evidence