HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Rosuvastatin impurity 42
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | tert-Butyl 2,4-dideoxy-3,5-O-(1-methylethylidene)-D-erythro-hexonate | HCID 9816650 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Rosuvastatin impurity 42 | HCID 18642009 | — |
Reaction Steps
Mixture of tert-butyl 2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (200 grams), sodium hydroxide (62 grams) in tetrahydrofuran (400 ml) was heated to reflux temperature and stirred up to completion of the reaction. The solvent from the reaction mixture was distilled off completely under reduced pressure at below 70° C. to get the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987444B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-57f705901180459583505b5e4ab0384f |
| Source note | uspto-grants-2015_03 |