反应详情

温度

65 °C

Mixture of tert-butyl 2-((4R,6S)-6-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate (50 grams), methanol (300 ml) and n-butyl amine (200 ml) was heated to 60-70° C. under nitrogen pressure and stirred. After the completion of the reaction, distilled off the reaction mixture completely followed by co-distillation with methylene chloride at below 55° C. Methylene chloride (500 ml) was added to the obtained residue at 25-30° C. and stirred for 15 minutes. The unwanted solid was filtered off and the filtrate was distilled off under reduced pressure to get the title compound.

1. customAfter the completion of the reaction
2. distillationdistilled off the reaction mixture
3. customcompletely followed by co-distillation with methylene chloride at below 55° C
4. additionMethylene chloride (500 ml) was added to the obtained residue at 25-30° C.
5. stirringstirred for 15 minutes
6. filtrationThe unwanted solid was filtered off
7. distillationthe filtrate was distilled off under reduced pressure