(4-Fluoro-2-methoxyphenyl)boronic acid → HCID 70663541, compound

HRID 877991Notes

Reaction equation

HRID 877991 reaction equation
[C:1]([O:5][C:6](=[O:21])[N:7]([C:14]1[CH:15]=[N:16][CH:17]=[CH:18][C:19]=1I)[CH2:8][C:9]1[O:10][CH:11]=[CH:12][N:13]=1)([CH3:4])([CH3:3])[CH3:2].[F:22][C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[C:25]([O:32][CH3:33])[CH:24]=1>CCCCCCC.CCOC(C)=O>[C:1]([O:5][C:6](=[O:21])[N:7]([C:14]1[CH:15]=[N:16][CH:17]=[CH:18][C:19]=1[C:26]1[CH:27]=[CH:28][C:23]([F:22])=[CH:24][C:25]=1[O:32][CH3:33])[CH2:8][C:9]1[O:10][CH:11]=[CH:12][N:13]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 2782672(4-Fluoro-2-methoxyphenyl)boronic acidHCID 70663390HCID 70663390, compound

Product 1

HCID 70663541HCID 70663541, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-yl)-oxazol-2-ylmethyl-carbamic acid tert-butyl ester and 4-fluoro-2-methoxyphenyl-boronic acid (CAS RN 179899-07-1) and using a gradient of n-heptane:EtOAc (100:0 to 0:100) for the chromatographic purification. Colorless solid (70%). MS (ESI): m/z=400.167 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-8a7f70393d6a4ea5ae5c3dc122d35e75
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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