(4-Iodo-pyridin-3-YL)-carbamic acid tert-butyl ester → HCID 70663390, compound

HRID 877992Notes

Reaction equation

HRID 877992 reaction equation
[C:1]([O:5][C:6](=[O:15])[NH:7][C:8]1[CH:9]=[N:10][CH:11]=[CH:12][C:13]=1[I:14])([CH3:4])([CH3:3])[CH3:2].Cl[CH2:17][C:18]1[O:19][CH:20]=[CH:21][N:22]=1>>[C:1]([O:5][C:6](=[O:15])[N:7]([C:8]1[CH:9]=[N:10][CH:11]=[CH:12][C:13]=1[I:14])[CH2:17][C:18]1[O:19][CH:20]=[CH:21][N:22]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 15366413(4-Iodo-pyridin-3-YL)-carbamic acid tert-butyl ester2×HCID 219575432-(Chloromethyl)-1,3-oxazole

Product 1

HCID 70663390HCID 70663390, compound

Procedure

The title compound was prepared in analogy to example 85, intermediate c, from (4-iodo-pyridin-3-yl)-carbamic acid tert-butyl ester (example 85, intermediate d) and 2-chloromethyl-oxazole (CAS RN 185246-17-7). Light yellow oil (93%). MS (ESI): m/z=402.031 [M+H]+.

Sources & evidence

ORD record
ord-f0e86180487341ccbea7fcbe95063774
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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