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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 878009Generated: October 31, 2026

(3-Methylpyridin-4-yl)boronic acid → N-Methyl-N-(3'-methyl-[4,4']bipyridinyl-3-yl)-3,5-bis-trifluoromethyl-benzamide

https://huagongshe.com/reaction/878009

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3-Methylpyridin-4-yl)boronic acidHCID 44754762—
ReactantN-(4-bromo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamideHCID 86670692—
SolventDimethylformamideHCID 6228—
ProductN-Methyl-N-(3'-methyl-[4,4']bipyridinyl-3-yl)-3,5-bis-trifluoromethyl-benzamideHCID 60197299—

Reaction Steps

The title compound was prepared in analogy to example 25, from N-(4-bromo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide (example 25, intermediate a) and 3-methylpyridine-4-boronic acid (CAS RN 894808-72-1) and using DMF as solvent for the reaction. Colorless solid (13%). MS (ESI): m/z=440.2 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08987307B2
Source datasetuspto-grants-2015_03
ORD IDord-5a3b2bf99c564ef794f9cde4fb6c783f
Source noteuspto-grants-2015_03