HuagongsheHuagongshe Chemistry Print Report · For research reference only
B-(3-Fluoro-2-methoxyphenyl)boronic acid → N-[4-(3-Fluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | B-(3-Fluoro-2-methoxyphenyl)boronic acid | HCID 21931617 | — |
| Reactant | N-(4-bromo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide | HCID 86670692 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-[4-(3-Fluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide | HCID 60196808 | — |
Reaction Steps
The title compound was prepared in analogy to example 25, from N-(4-bromo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide (example 25, intermediate a) and 3-fluoro-2-methoxyphenylboronic acid (CAS RN 762287-59-2) and using DMF as reaction solvent. Off-white solid (27%). MS (ESI): m/z=473.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-7555814c210c4ca999a604c8b3fef583 |
| Source note | uspto-grants-2015_03 |