HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxy-6-methylpyridine-3-boronic acid → N-(2-Methoxy-6-methyl-[3,4']bipyridinyl-3'-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxy-6-methylpyridine-3-boronic acid | HCID 2763121 | — |
| Reactant | N-(4-bromo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide | HCID 86670692 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(2-Methoxy-6-methyl-[3,4']bipyridinyl-3'-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide | HCID 60196809 | — |
Reaction Steps
The title compound was prepared in analogy to example 25, from N-(4-bromo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide (example 25, intermediate a) and 2-methoxy-6-methylpyridine-3-boronic acid (CAS RN 1000802-75-4) and using DMF as reaction solvent. Off-white solid (42%). MS (ESI): m/z=469.8 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-e88e95f73c4c44659b64f7e2948868ba |
| Source note | uspto-grants-2015_03 |