HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroethanol → N-{4-[4-Fluoro-2-(2-hydroxy-ethoxy)-phenyl]-pyridin-3-yl}-N-methyl-3,5-bis-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroethanol | HCID 34 | — |
| Reactant | N-[4-(4-Fluoro-2-hydroxy-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide | HCID 136209610 | — |
| Product | N-{4-[4-Fluoro-2-(2-hydroxy-ethoxy)-phenyl]-pyridin-3-yl}-N-methyl-3,5-bis-trifluoromethyl-benzamide | HCID 86670702 | — |
Reaction Steps
The title compound was prepared in analogy to example 49, from N-[4-(4-fluoro-2-hydroxy-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide (example 48) and 2-chloroethanol (CAS RN 107-07-3). Off-white solid (62%). MS (ESI): m/z=502.9 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-63da451bb164442ba46dcb5b28d2efed |
| Source note | uspto-grants-2015_03 |