2-Bromopropionitrile → N-{4-[2-(Cyano-methyl-methoxy)-4-fluoro-phenyl]-pyridin-3-yl}-N-methyl-3,5-bis-trifluoromethyl-benzamide

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-Bromopropionitrile	HCID 140538	—
Edukt	N-[4-(4-Fluoro-2-hydroxy-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide	HCID 136209610	—
Produkt	N-{4-[2-(Cyano-methyl-methoxy)-4-fluoro-phenyl]-pyridin-3-yl}-N-methyl-3,5-bis-trifluoromethyl-benzamide	HCID 86670703	—

Reaktionsschritte

The title compound was prepared in analogy to example 49, from N-[4-(4-fluoro-2-hydroxy-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide (example 48) and 2-bromopropionitrile (CAS RN 19481-82-4). Off-white solid (74%). MS (ESI): m/z =512.0 [M+H]+.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08987307B2
Quelldatensatz	uspto-grants-2015_03
ORD ID	ord-2390cbe5fe9749e1ac6cf1cc32222f3c
Quellennotiz	uspto-grants-2015_03