3,5-Bis(trifluoromethyl)benzoyl chloride → N-Methyl-N-(3-methyl-[2,4']bipyridinyl-3'-yl)-3,5-bis-trifluoromethyl-benzamide

HRID 878036Notes

Reaction equation

HRID 878036 reaction equation
[CH3:1][NH:2][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[C:9]1[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][N:10]=1.[F:16][C:17]([F:32])([F:31])[C:18]1[CH:19]=[C:20]([CH:24]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:26]=1)[C:21](Cl)=[O:22]>>[CH3:1][N:2]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[C:9]1[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][N:10]=1)[C:21](=[O:22])[C:20]1[CH:24]=[C:25]([C:27]([F:28])([F:29])[F:30])[CH:26]=[C:18]([C:17]([F:16])([F:31])[F:32])[CH:19]=1

Participants

3

Reactant 2

HCID 1018563,5-Bis(trifluoromethyl)benzoyl chlorideHCID 70663197Methyl-(3-methyl-[2,4]bipyridinyl-3'-yl)-amine

Product 1

HCID 60197499N-Methyl-N-(3-methyl-[2,4']bipyridinyl-3'-yl)-3,5-bis-trifluoromethyl-benzamide

Procedure

The title compound was prepared in analogy to example 55, from methyl-(3-methyl-[2,4]bipyridinyl-3′-yl)-amine and 3,5-bis(trifluoromethyl)benzoyl chloride (CAS RN 1271-19-8) and using preparative HPLC for the chromatographic purification. Off-white solid (20%). MS (ESI): m/z=440.4 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-5c987a234990430cac48472350df357a
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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