3,5-Difluoro-2-methoxyphenylboronic acid → HCID 60197497, compound

HRID 878039Notes

Reaction equation

HRID 878039 reaction equation
Br[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N:8]([CH3:25])[C:9](=[O:24])[C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:23])([F:22])[F:21])[CH:11]=1.[CH3:26][O:27][C:28]1[C:33]([F:34])=[CH:32][C:31]([F:35])=[CH:30][C:29]=1B(O)O>>[F:34][C:33]1[C:28]([O:27][CH3:26])=[C:29]([C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[N:8]([CH3:25])[C:9](=[O:24])[C:10]2[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[C:12]([C:20]([F:23])([F:22])[F:21])[CH:11]=2)[CH:30]=[C:31]([F:35])[CH:32]=1

Participants

3

Reactant 2

HCID 27346073,5-Difluoro-2-methoxyphenylboronic acidHCID 86670692N-(4-bromo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide

Product 1

HCID 60197497HCID 60197497, compound

Procedure

The title compound was prepared in analogy to example 58, from N-(4-bromo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide (example 25, intermediate a) and 2-methoxy-3,5-difluorophenylboronic acid (CAS RN 737000-76-9) and using preparative HPLC for the chromatographic purification. Off-white solid (49%). MS (ESI): m/z=491.1 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-3323fb3b0594436985f4325a0c788bd1
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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