3,5-Bis(trifluoromethyl)benzoyl chloride → N-(6-Chloro-[2,4']bipyridinyl-3'-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide

HRID 878054Notes

Reaction equation

HRID 878054 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][C:9]=2[NH:14][CH3:15])[CH:5]=[CH:4][CH:3]=1.[F:16][C:17]([F:32])([F:31])[C:18]1[CH:19]=[C:20]([CH:24]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:26]=1)[C:21](Cl)=[O:22]>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][C:9]=2[N:14]([CH3:15])[C:21](=[O:22])[C:20]2[CH:19]=[C:18]([C:17]([F:32])([F:31])[F:16])[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=2)[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 1018563,5-Bis(trifluoromethyl)benzoyl chlorideHCID 86670716(6-Chloro-[2,4]bipyridinyl-3'-yl)-methyl-amine

Product 1

HCID 86670715N-(6-Chloro-[2,4']bipyridinyl-3'-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide

Procedure

The title compound was prepared in analogy to example 55, from (6-chloro-[2,4]bipyridinyl-3′-yl)-methyl-amine and 3,5-bis(trifluoromethyl)benzoyl chloride (CAS RN 1271-19-8) and using preparative HPLC for the purification. Off-white sticky solid (20%). MS (ESI): m/z=460.2 [M+H]+.

Workup

  1. customfor the purification

Sources & evidence

ORD record
ord-94bd63c06c55432fb37997875a4862bf
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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