HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5-Chloro-2-fluoro-4-iodopyridine → US10385022, Example 87
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5-Chloro-2-fluoro-4-iodopyridine | HCID 21865336 | — |
| Edukt | N-[6-Chloro-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide | HCID 86670717 | — |
| Lösungsmittel | Ethylacetate heptane | HCID 21899848 | — |
| Produkt | US10385022, Example 87 | HCID 60197695 | — |
Reaktionsschritte
The title compound was prepared in analogy to example 73, from N-(6-chloro-4-iodo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide (example 72, intermediate) and 5-chloro-2-fluoro-4-iodopyridine (CAS RN 659731-48-3) and using a gradient of n-heptane:EtOAc (100:0 to 30:70) for the chromatographic separation. Colorless oil (89%). MS (ESI): m/z=511.009 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08987307B2 |
| Quelldatensatz | uspto-grants-2015_03 |
| ORD ID | ord-4488c24809784d5ab726d7869d99ee8b |
| Quellennotiz | uspto-grants-2015_03 |