2-Chlorophenylboronic acid → HCID 70663162, compound

HRID 878079Notes

Reaction equation

HRID 878079 reaction equation
[CH3:1][O:2][C:3](=[O:20])[CH2:4][N:5]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[C:6]1[CH:7]=[N:8][CH:9]=[CH:10][C:11]=1I.[Cl:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1B(O)O>CCCCCCC.CCOC(C)=O>[CH3:1][O:2][C:3](=[O:20])[CH2:4][N:5]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[C:6]1[CH:7]=[N:8][CH:9]=[CH:10][C:11]=1[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=1[Cl:21]

Participants

4

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 70663361HCID 70663361, compound

Product 1

HCID 70663162HCID 70663162, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared in analogy to example 72, from [tert-butoxycarbonyl-(4-iodo-pyridin-3-yl)-amino]-acetic acid methyl ester and 2-chlorophenylboronic acid (CAS RN 1679-18-1) and using a gradient of n-heptane:EtOAc (100:0 to 60:40) for the chromatographic purification. Colorless oil (49%). MS (ESI): m/z=377.126 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-6243ccabf13448e5b4aa0e58224b2496
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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