2-Chlorophenylboronic acid → HCID 70663545, compound

HRID 878082Notes

Reaction equation

HRID 878082 reaction equation
[C:1]([O:5][C:6](=[O:19])[N:7]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][C:17]=1I)[CH2:8][CH2:9][O:10][CH3:11])([CH3:4])([CH3:3])[CH3:2].[Cl:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1B(O)O>CCCCCCC.CCOC(C)=O>[C:1]([O:5][C:6](=[O:19])[N:7]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][C:17]=1[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[Cl:20])[CH2:8][CH2:9][O:10][CH3:11])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 70663205HCID 70663205, compound

Product 1

HCID 70663545HCID 70663545, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-yl)-(2-methoxy-ethyl)-carbamic acid tert-butyl ester and 2-chlorophenylboronic acid (CAS RN 1679-18-1) and using a gradient of n-heptane:EtOAc (100:0 to 50:50) for the chromatographic purification. Colorless oil (70%). MS (ESI): m/z=363.147 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-5cb90727ccc440058cf6b6098bab8506
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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