HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Fluoro-4-(trifluoromethyl)benzoic acid → 3-Fluoro-N-methyl-N-(4-o-tolyl-pyridin-3-yl)-4-trifluoromethyl-benzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Fluoro-4-(trifluoromethyl)benzoic acid | HCID 688293 | — |
| Edukt | N-methyl-4-o-tolylpyridin-3-amine | HCID 18403336 | — |
| Lösungsmittel | Ethylacetate heptane | HCID 21899848 | — |
| Produkt | 3-Fluoro-N-methyl-N-(4-o-tolyl-pyridin-3-yl)-4-trifluoromethyl-benzamide | HCID 70663305 | — |
Reaktionsschritte
The title compound was prepared in analogy to example 90, from N-methyl-4-o-tolylpyridin-3-amine (example 1, intermediate a) and 3-fluoro-4-(trifluoromethyl)benzoic acid (CAS RN 115754-21-7) and using a gradient of n-heptane:EtOAc (100:0 to 0:100) for the chromatographic purification. Light brown solid (20%). MS (ESI): m/z=389.13 [M+H]+.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08987307B2 |
| Quelldatensatz | uspto-grants-2015_03 |
| ORD ID | ord-2c304b31764f4b489a4752048e087345 |
| Quellennotiz | uspto-grants-2015_03 |