4-Chloro-3-(trifluoromethyl)benzoic acid → HCID 60197697, compound

HRID 878088Notes

Reaction equation

HRID 878088 reaction equation
[CH3:1][NH:2][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH3:15].[Cl:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([OH:23])=O)=[CH:19][C:18]=1[C:26]([F:29])([F:28])[F:27]>CCCCCCC.CCOC(C)=O>[Cl:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([N:2]([CH3:1])[C:3]2[CH:4]=[N:5][CH:6]=[CH:7][C:8]=2[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[CH3:15])=[O:23])=[CH:19][C:18]=1[C:26]([F:29])([F:28])[F:27]

Participants

4

Reactant 2

HCID 27738574-Chloro-3-(trifluoromethyl)benzoic acidHCID 18403336N-methyl-4-o-tolylpyridin-3-amine

Product 1

HCID 60197697HCID 60197697, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared in analogy to example 90, from N-methyl-4-o-tolylpyridin-3-amine (example 1, intermediate a) and 4-chloro-3-(trifluoromethyl)benzoic acid (CAS RN 1737-36-6) and using a gradient of n-heptane:EtOAc (100:0 to 0:100) for the chromatographic purification. Light brown solid (30%). MS (ESI): m/z=405.10 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-026e8d1d2f6a461fbc34d50daa064af8
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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