3,5-Dimethylbenzoic acid → HCID 60197698, compound

HRID 878089Notes

Reaction equation

HRID 878089 reaction equation
[CH3:1][NH:2][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH3:15].[CH3:16][C:17]1[CH:18]=[C:19]([CH:23]=[C:24]([CH3:26])[CH:25]=1)[C:20]([OH:22])=O>CCCCCCC.CCOC(C)=O>[CH3:26][C:24]1[CH:23]=[C:19]([CH:18]=[C:17]([CH3:16])[CH:25]=1)[C:20]([N:2]([CH3:1])[C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH3:15])=[O:22]

Participants

4

Reactant 2

HCID 103563,5-Dimethylbenzoic acidHCID 18403336N-methyl-4-o-tolylpyridin-3-amine

Product 1

HCID 60197698HCID 60197698, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared in analogy to example 90, from N-methyl-4-o-tolylpyridin-3-amine (example 1, intermediate a) and 3,5-dimethylbenzoic acid (CAS RN 499-06-9) and using a gradient of n-heptane:EtOAc (100:0 to 0:100) for the chromatographic purification. Brown oil (3%). MS (ESI): m/z=331.18 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-8a5f81993dfe4c7897324155622ef7fc
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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