HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-5-(trifluoromethoxy)benzoic acid → 3-Chloro-N-methyl-N-(4-o-tolyl-pyridin-3-yl)-5-trifluoromethoxy-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-5-(trifluoromethoxy)benzoic acid | HCID 17750735 | — |
| Reactant | N-methyl-4-o-tolylpyridin-3-amine | HCID 18403336 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | 3-Chloro-N-methyl-N-(4-o-tolyl-pyridin-3-yl)-5-trifluoromethoxy-benzamide | HCID 70663566 | — |
Reaction Steps
The title compound was prepared in analogy to example 90, from N-methyl-4-o-tolylpyridin-3-amine (example 1, intermediate a) and 3-chloro-5-(trifluoromethoxy)benzoic acid (CAS RN 158580-93-9) and using a gradient of n-heptane:EtOAc (100:0 to 50:50) for the chromatographic purification. Yellow solid (31%). MS (ESI): m/z=421.09 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-062ceab46b7f45f783c105bf9c76a613 |
| Source note | uspto-grants-2015_03 |