HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-5-fluorobenzoic acid → 3-Chloro-5-fluoro-N-methyl-N-(4-o-tolyl-pyridin-3-yl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-5-fluorobenzoic acid | HCID 2734840 | — |
| Reactant | N-methyl-4-o-tolylpyridin-3-amine | HCID 18403336 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | 3-Chloro-5-fluoro-N-methyl-N-(4-o-tolyl-pyridin-3-yl)-benzamide | HCID 70663370 | — |
Reaction Steps
The title compound was prepared in analogy to example 90, from N-methyl-4-o-tolylpyridin-3-amine (example 1, intermediate a) and 3-chloro-5-fluorobenzoic acid (CAS RN 25026-64-6) and using a gradient of n-heptane:EtOAc (100:0 to 30:70) for the chromatographic purification. Yellow solid (17%). MS (ESI): m/z=355.10 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-f2c89beae8e1432691acb382d43de154 |
| Source note | uspto-grants-2015_03 |