HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dimethylphenylboronic acid → N-[4-(2,3-Dimethyl-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dimethylphenylboronic acid | HCID 2773395 | — |
| Reactant | N-(4-iodopyridin-3-yl)-N-methyl-3,5-bis(trifluoromethyl)benzamide | HCID 86670697 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | N-[4-(2,3-Dimethyl-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide | HCID 86670727 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from N-(4-iodo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide (example 98, intermediate a) and 2,3-dimethylphenylboronic acid (CAS RN 183158-34-1) and using gradient of n-heptane:EtOAc (100:0 to 30:70) for the chromatographic purification. Colorless solid (81%). MS (ESI): m/z=453.140 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-bbacee8cc041429392bf0145586183cf |
| Source note | uspto-grants-2015_03 |