HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-(2,2,2-Trifluoroethoxy)pyridin-3-yl)boronic acid → N-Methyl-N-[2-(2,2,2-trifluoro-ethoxy)-[3,4']bipyridinyl-3'-yl]-3,5-bis-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-(2,2,2-Trifluoroethoxy)pyridin-3-yl)boronic acid | HCID 53216590 | — |
| Reactant | N-(4-iodopyridin-3-yl)-N-methyl-3,5-bis(trifluoromethyl)benzamide | HCID 86670697 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | N-Methyl-N-[2-(2,2,2-trifluoro-ethoxy)-[3,4']bipyridinyl-3'-yl]-3,5-bis-trifluoromethyl-benzamide | HCID 86670728 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from N-(4-iodo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide (example 98, intermediate a) and 2-(2,2,2-trifluoroethoxy)pyridin-3-ylboronic acid (Combi-Blocks Inc.) and using a gradient of n-heptane:EtOAc (100:0 to 30:70) for the chromatographic purification. Colorless solid (58%). MS (ESI): m/z=524.103 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-0c67abd07d4d41f9a397b8ed7f6811f7 |
| Source note | uspto-grants-2015_03 |