HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Cyclopropylmethoxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → HCID 86670729, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Cyclopropylmethoxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | HCID 17750193 | — |
| Reactant | N-(4-iodopyridin-3-yl)-N-methyl-3,5-bis(trifluoromethyl)benzamide | HCID 86670697 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | HCID 86670729 | HCID 86670729 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from N-(4-iodo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide (example 98, intermediate a) and 2-(cyclopropylmethoxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS RN 848243-26-5) and using a gradient of n-heptane:EtOAc (100:0 to 30:70) for the chromatographic purification. Light yellow oil (63%). MS (ESI): m/z=498.146 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-1fd836ec06724742b52d6ddaecec4208 |
| Source note | uspto-grants-2015_03 |