2-Chlorophenylboronic acid → HCID 70663182, compound

HRID 878109Notes

Reaction equation

HRID 878109 reaction equation
[C:1]([O:5][C:6](=[O:21])[N:7]([C:14]1[CH:15]=[N:16][CH:17]=[CH:18][C:19]=1I)[CH2:8][CH2:9][S:10]([CH3:13])(=[O:12])=[O:11])([CH3:4])([CH3:3])[CH3:2].[Cl:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1B(O)O>>[C:1]([O:5][C:6](=[O:21])[N:7]([C:14]1[CH:15]=[N:16][CH:17]=[CH:18][C:19]=1[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=1[Cl:22])[CH2:8][CH2:9][S:10]([CH3:13])(=[O:12])=[O:11])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 70663164HCID 70663164, compound

Product 1

HCID 70663182HCID 70663182, compound

Procedure

The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-yl)-(2-methanesulfonyl-ethyl)-carbamic acid tert-butyl ester and 2-chlorophenylboronic acid (CAS RN 1679-18-1). The product was purified by preparative HPLC (phenomenex gemini column) with a gradient of acetonitrile:water (containing 0.05% formic acid) (10:90 to 98:2). Light brown foam (67%). MS (ESI): m/z=411.11 [M+H]+.

Workup

  1. customThe product was purified by preparative HPLC (phenomenex gemini column) with a gradient of acetonitrile

Sources & evidence

ORD record
ord-366e9fd18e9c41e7a4d03505711cf06c
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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