2-Chlorophenylboronic acid → HCID 86670739, compound

HRID 878117Notes

Reaction equation

HRID 878117 reaction equation
[C:1]([O:5][C:6](=[O:19])[N:7]([CH2:15][CH:16]([F:18])[F:17])[C:8]1[CH:9]=[N:10][CH:11]=[CH:12][C:13]=1I)([CH3:4])([CH3:3])[CH3:2].[Cl:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1B(O)O>CCCCCCC.CCOC(C)=O>[C:1]([O:5][C:6](=[O:19])[N:7]([C:8]1[CH:9]=[N:10][CH:11]=[CH:12][C:13]=1[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[Cl:20])[CH2:15][CH:16]([F:18])[F:17])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 86670740HCID 86670740, compound

Product 1

HCID 86670739HCID 86670739, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared in analogy to example 72, from (2,2-difluoro-ethyl)-(4-iodo-pyridin-3-yl)-carbamic acid tert-butyl ester and 2-chlorophenylboronic acid (CAS RN 1679-18-1) and using a gradient of n-heptane:EtOAc (100:0 to 50:50) for the chromatographic purification. Light brown oil (0.726 g; 89%). MS (ESI): m/z=369.12 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-36f1c4c64ad9474eaf700128f1a63f8b
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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