4,6-Dimethylpicolinic acid → HCID 70663543, compound

HRID 878122Notes

Reaction equation

HRID 878122 reaction equation
[CH3:1][NH:2][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH3:15].[CH3:16][C:17]1[CH:22]=[C:21]([CH3:23])[N:20]=[C:19]([C:24](O)=[O:25])[CH:18]=1>>[CH3:1][N:2]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH3:15])[C:24]([C:19]1[CH:18]=[C:17]([CH3:16])[CH:22]=[C:21]([CH3:23])[N:20]=1)=[O:25]

Participants

3

Reactant 2

HCID 6932954,6-Dimethylpicolinic acidHCID 18403336N-methyl-4-o-tolylpyridin-3-amine

Product 1

HCID 70663543HCID 70663543, compound

Procedure

The title compound was prepared in analogy to example 90, from N-methyl-4-o-tolylpyridin-3-amine (example 1, intermediate a) and 4,6-dimethylpyridine-2-carboxylic acid (CAS RN 18088-10-3) after a reaction time of 64 hours. The compound was purified by silica gel chromatography on a 10 g column using a MPLC system eluting with a gradient of n-heptane:EtOAc (100:0 to 0:100). Light brown oil (37%). MS (ESI): m/z=332.18 [M+H]+.

Workup

  1. customThe compound was purified by silica gel chromatography on a 10 g column
  2. washeluting with a gradient of n-heptane:EtOAc (100:0 to 0:100)

Sources & evidence

ORD record
ord-e45b922c1f234ef79d5e1e011b016a2f
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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