4,6-Dichloropyridine-2-carboxylic acid → HCID 86670745, compound

HRID 878124Notes

Reaction equation

HRID 878124 reaction equation
[CH3:1][NH:2][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH3:15].[Cl:16][C:17]1[CH:22]=[C:21]([Cl:23])[N:20]=[C:19]([C:24](O)=[O:25])[CH:18]=1>CCCCCCC.CCOC(C)=O>[CH3:1][N:2]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[CH3:15])[C:24]([C:19]1[CH:18]=[C:17]([Cl:16])[CH:22]=[C:21]([Cl:23])[N:20]=1)=[O:25]

Participants

4

Reactant 2

HCID 120874534,6-Dichloropyridine-2-carboxylic acidHCID 18403336N-methyl-4-o-tolylpyridin-3-amine

Product 1

HCID 86670745HCID 86670745, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared in analogy to example 90, from N-methyl-4-o-tolylpyridin-3-amine (example 1, intermediate a) and 4,6-dichloro-pyridine-2-carboxylic acid (CAS RN 88912-25-8) and using a gradient of n-heptane:EtOAc (100:0 to 0:100) for the chromatographic purification. Colorless solid (7%). MS (ESI): m/z=372.07 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-2a917ddbcbee452d849606bbf4e58f02
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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