HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-5-(trifluoromethyl)benzoyl chloride → N-[4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-3-fluoro-N-methyl-5-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-5-(trifluoromethyl)benzoyl chloride | HCID 519364 | — |
| Reactant | [4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-methyl-amine | HCID 70663277 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | N-[4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-3-fluoro-N-methyl-5-trifluoromethyl-benzamide | HCID 86670751 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, intermediate, from [4-(4,5-difluoro-2-methoxy-phenyl)-pyridin-3-yl]-methyl-amine and 3-fluoro-5-(trifluoromethyl)benzoic acid chloride (CAS RN 171243-30-4) and using a gradient of n-heptane:EtOAc (100:0 to 20:80) for the chromatographic purification. Yellow solid (33%). MS (ESI): m/z=441.103 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-4d15b9342fa9412db0f8ee4e61e0e6ff |
| Source note | uspto-grants-2015_03 |