HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4,5-Difluoro-2-methoxyphenyl)boronic acid → [4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-methyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4,5-Difluoro-2-methoxyphenyl)boronic acid | HCID 16217679 | — |
| Reactant | N-Methyl-N-(2-methyl-3,4,5,6-tetrahydro-2H-[1,4']bipyridinyl-3'-yl)-3,5-bis-trifluoromethyl-benzamide | HCID 86670691 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | [4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-methyl-amine | HCID 70663277 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-yl)-methyl-amine (example 98, intermediate b) and 4,5-difluoro-2-methoxyphenylboronic acid (CAS RN 870777-32-5) and using a gradient of n-heptane:EtOAc (100:0 to 50:50) for the chromatographic separation. Light brown solid (91%). MS (ESI): m/z=251.099 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-6a317d13bc4f49ae825694ead9d3cd9d |
| Source note | uspto-grants-2015_03 |