HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methyl-4-o-tolylpyridin-3-amine → N-Methyl-N-(4-o-tolyl-pyridin-3-yl)-2,6-bis-trifluoromethyl-isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-methyl-4-o-tolylpyridin-3-amine | HCID 18403336 | — |
| Reactant | 2,6-Bis(trifluoromethyl)pyridine-4-carboxylic acid | HCID 30689135 | — |
| Product | N-Methyl-N-(4-o-tolyl-pyridin-3-yl)-2,6-bis-trifluoromethyl-isonicotinamide | HCID 60197806 | — |
Reaction Steps
The title compound was prepared in analogy to example 90, from N-methyl-4-o-tolylpyridin-3-amine (example 1, intermediate a) and 2,6-bis(trifluoromethyl)isonicotinic acid (Key Organics Ltd.). The compound was purified by silica gel chromatography using a MPLC system (CombiFlash Companion, Isco Inc.) eluting with a gradient of CH2Cl2: EtOAc (100:0 to 70:30). Light yellow foam (61%). MS (ESI): m/z=440.118 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-01ea1928d26145a793c8fd0d18257b96 |
| Source note | uspto-grants-2015_03 |