反应详情

The title compound was prepared in analogy to example 90, from [4-(4-fluoro-2-methoxy-phenyl)-pyridin-3-yl]-methyl-amine (example 129, intermediate a) and 3-methanesulfonyl-5-trifluoromethyl-benzoic acid (example 114, intermediate a) after a reaction time of 72 hours. The compound was purified by silica gel chromatography using a MPLC system (CombiFlash Companion, Isco Inc.) eluting with a gradient of n-heptane:EtOAc (100:0 to 50:50), followed by preparative HPLC using a gradient of methanol:water (10:90 to 95:5). Colorless foam (44%). MS (ESI): m/z=483.099 [M+H]+.

1. customThe compound was purified by silica gel chromatography
2. washeluting with a gradient of n-heptane:EtOAc (100:0 to 50:50)