HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylphenyl boronic acid → (4-o-Tolyl-pyridin-3-yl)-(2,2,2-trifluoro-ethyl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylphenyl boronic acid | HCID 2733267 | — |
| Reactant | 3-Pyridinamine, 4-iodo-N-(2,2,2-trifluoroethyl)- | HCID 70663514 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | (4-o-Tolyl-pyridin-3-yl)-(2,2,2-trifluoro-ethyl)-amine | HCID 70663500 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-yl)-(2,2,2-trifluoro-ethyl)-amine and 2-methylphenylboronic acid (CAS RN 16419-60-6) and using a gradient of n-heptane:EtOAc (100:0 to 50:50) for the chromatographic purification. Light brown solid (91%). MS (ESI): m/z=267.11 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-0b23271aa79b4fc8a4db2f2e134fa8d0 |
| Source note | uspto-grants-2015_03 |