HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Fluoro-2-methoxyphenyl)boronic acid → (2,2-Difluoro-ethyl)-[4-(4-fluoro-2-methoxy-phenyl)-pyridin-3-yl]amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Fluoro-2-methoxyphenyl)boronic acid | HCID 2782672 | — |
| Reactant | 3-Pyridinamine, N-(2,2-difluoroethyl)-4-iodo- | HCID 86670764 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | (2,2-Difluoro-ethyl)-[4-(4-fluoro-2-methoxy-phenyl)-pyridin-3-yl]amine | HCID 86670763 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from (2,2-difluoro-ethyl)-(4-iodo-pyridin-3-yl)-amine and 4-fluoro-2-methoxyphenylboronic acid (CAS RN 179899-07-1) and using a gradient of n-heptane:EtOAc (100:0 to 50:50) for the chromatographic purification. Light brown solid (78%). MS (ESI): m/z=283.18 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-6a88efdb49f940438b758a7d36dd22e4 |
| Source note | uspto-grants-2015_03 |