HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Methoxypyridin-3-yl)boronic acid → (2,2-Difluoro-ethyl)-(2-methoxy-[3,4]bipyridinyl-3'-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Methoxypyridin-3-yl)boronic acid | HCID 2762709 | — |
| Reactant | HCID 60198028 | HCID 60198028 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | (2,2-Difluoro-ethyl)-(2-methoxy-[3,4]bipyridinyl-3'-yl)-amine | HCID 86670768 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from (2,2-difluoro-ethyl)-(4-iodo-pyridin-3-yl)-amine (example 153, intermediate b) and 2-methoxypyridine-3-boronic acid (CAS RN 163105-90-6) and using a gradient of n-heptane:EtOAc (100:0 to 50:50) for the chromatographic purification. Colorless solid (83%). MS (ESI): m/z=266.11 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-cb229144b5c64a4ebd6940f85caac8d1 |
| Source note | uspto-grants-2015_03 |