HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylphenyl boronic acid → (2,2-Difluoro-ethyl)-(4-o-tolyl-pyridin-3-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylphenyl boronic acid | HCID 2733267 | — |
| Reactant | HCID 60198028 | HCID 60198028 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | (2,2-Difluoro-ethyl)-(4-o-tolyl-pyridin-3-yl)-amine | HCID 86670770 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from (2,2-difluoro-ethyl)-(4-iodo-pyridin-3-yl)-amine (example 153, intermediate b) and 2-methylphenylboronic acid (CAS RN 16419-60-6) and using a gradient of n-heptane:EtOAc (100:0 to 50:50) for the chromatographic purification. Colorless solid (93%). MS (ESI): m/z=248.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-427c2f2422254f098c62ede10b6bc5ba |
| Source note | uspto-grants-2015_03 |