HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4,5-Difluoro-2-methoxyphenyl)boronic acid → [4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-(2-methanesulfonyl-ethyl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4,5-Difluoro-2-methoxyphenyl)boronic acid | HCID 16217679 | — |
| Reactant | (4-Iodo-pyridin-3-yl)-(2-methanesulfonyl-ethyl)-amine | HCID 70663351 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | [4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-(2-methanesulfonyl-ethyl)-amine | HCID 70663311 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-yl)-(2-methanesulfonyl-ethyl)-amine and 4,5-difluoro-2-methoxyphenylboronic acid (CAS RN 870777-32-5) and using a gradient of CH2Cl2:methanol (100:0 to 85:15) for the chromatographic purification. Light brown foam (76%). MS (ESI): m/z=343.09 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-a9c58b8fbbf54b78b3791faf96a5d3f4 |
| Source note | uspto-grants-2015_03 |