HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluorophenylboronic acid → [4-(2-Fluoro-phenyl)-pyridin-3-yl]-(2-methanesulfonyl-ethyl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluorophenylboronic acid | HCID 2734354 | — |
| Reactant | N-[4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-(2-methanesulfonyl-ethyl)-2,6-bis-trifluoromethyl-isonicotinamide | HCID 86670771 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | [4-(2-Fluoro-phenyl)-pyridin-3-yl]-(2-methanesulfonyl-ethyl)-amine | HCID 70663435 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-yl)-(2-methanesulfonyl-ethyl)-amine (example 158, intermediate b) and 2-fluorophenylboronic acid (CAS RN 1193-03-9) and using a gradient of CH2Cl2:methanol (100:0 to 70:30) for the chromatographic purification. Light brown solid (85%). MS (ESI): m/z=295.09 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-317730094407496daeaf7975b25b5f4c |
| Source note | uspto-grants-2015_03 |