2-Methylphenyl boronic acid → HCID 86670773, compound

HRID 878179Notes

Reaction equation

HRID 878179 reaction equation
I[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH:8][CH2:9][C:10]#[N:11].[CH3:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1B(O)O>CCCCCCC.CCOC(C)=O>[C:13]1([CH3:12])[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH:8][CH2:9][C:10]#[N:11]

Participants

4

Reactant 2

HCID 27332672-Methylphenyl boronic acidHCID 86670774HCID 86670774, compound

Product 1

HCID 86670773HCID 86670773, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-ylamino)-acetonitrile and 2-methylphenylboronic acid (CAS RN 16419-60-6) and using a gradient of n-heptane:EtOAc (100:0 to 0:100) for the chromatographic purification. Light brown solid (48%). MS (ESI): m/z=224.12 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-384a702408254452ba110d1584d4d88f
Source dataset
uspto-grants-2015_03
Patent number
US08987307B2

Reaction notes

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