HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methyl-4-o-tolylpyridin-3-amine → {3-[Methyl-(4-o-tolyl-pyridin-3-yl)-carbamoyl]-5-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-methyl-4-o-tolylpyridin-3-amine | HCID 18403336 | — |
| Reactant | 3-(((Tert-butoxy)carbonyl)amino)-5-(trifluoromethyl)benzoic acid | HCID 61235116 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | {3-[Methyl-(4-o-tolyl-pyridin-3-yl)-carbamoyl]-5-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester | HCID 70663415 | — |
Reaction Steps
The title compound was prepared in analogy to example 90, from N-methyl-4-o-tolylpyridin-3-amine (example 1, intermediate a) and 3-tert-butoxycarbonylamino-5-trifluoromethyl-benzoic acid and using a gradient of n-heptane:EtOAc (100:0 to 0:60) for the chromatographic purification. Light brown solid (4%). MS (ESI): m/z=486.20 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-c527e468dcf241f3947f06e777535315 |
| Source note | uspto-grants-2015_03 |