HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,6-dihydro-2H-pyran-4-yl trifluoromethanesulfonate → N-[4-(3,6-Dihydro-2H-pyran-4-yl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,6-dihydro-2H-pyran-4-yl trifluoromethanesulfonate | HCID 11356703 | — |
| Reactant | N-(4-iodopyridin-3-yl)-N-methyl-3,5-bis(trifluoromethyl)benzamide | HCID 86670697 | — |
| Product | N-[4-(3,6-Dihydro-2H-pyran-4-yl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide | HCID 86670777 | — |
Reaction Steps
The title compound was prepared in analogy to example 73, from N-(4-iodo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide (example 98, intermediate a) and trifluoro-methanesulfonic acid 3,6-dihydro-2H-pyran-4-yl ester (CAS RN 188975-30-6). The compound was purified by silica gel chromatography using a MPLC system (CombiFlash Companion, Isco Inc.) eluting with a gradient of n-heptane:EtOAc (100:0 to 40:60). Colorless solid (56%). MS (ESI): m/z=431.177 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-00fa3f8205344a738cab6760b7b9b3ce |
| Source note | uspto-grants-2015_03 |