HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,3-Dimethoxybenzeneboronic acid → [4-(2,3-Dimethoxy-phenyl)-pyridin-3-yl]-methyl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,3-Dimethoxybenzeneboronic acid | HCID 5156491 | — |
| Reactant | N-[4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-(2-methanesulfonyl-ethyl)-2,6-bis-trifluoromethyl-isonicotinamide | HCID 86670771 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | [4-(2,3-Dimethoxy-phenyl)-pyridin-3-yl]-methyl-amine | HCID 70663228 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-yl)-methyl-amine (example 98, intermediate b) and 2,3-dimethoxyphenylboronic acid (CAS RN 28611-39-4) and using a gradient of n-heptane:EtOAc (100:0 to 30:70) for the chromatographic purification. Light yellow solid (79%). MS (ESI): m/z=245.128 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-c369cf86c47b4affa9f9d9bf4de5ead8 |
| Source note | uspto-grants-2015_03 |