HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Ethylphenylboronic Acid (contains varying amounts of Anhydride) → HCID 70663292, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Ethylphenylboronic Acid (contains varying amounts of Anhydride) | HCID 4100862 | — |
| Reactant | N-[4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-(2-methanesulfonyl-ethyl)-2,6-bis-trifluoromethyl-isonicotinamide | HCID 86670771 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | HCID 70663292 | HCID 70663292 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-yl)-methyl-amine (example 36, intermediate b) and 2-ethylphenylboronic acid (CAS RN 90002-36-1) and using a gradient of n-heptane:EtOAc (100:0 to 40:60) for the chromatographic purification. Light yellow solid (87%). MS (ESI): m/z=213.138 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-b306b0e0928c440dbdbb7b6fb3544d73 |
| Source note | uspto-grants-2015_03 |