HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methanesulfonyl-5-(trifluoromethyl)benzoic acid → [[4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-(3-methanesulfonyl-5-trifluoromethyl-benzoyl)-amino]-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methanesulfonyl-5-(trifluoromethyl)benzoic acid | HCID 21544516 | — |
| Reactant | [4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-ylamino]-acetic acid methyl ester | HCID 70663491 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | [[4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-(3-methanesulfonyl-5-trifluoromethyl-benzoyl)-amino]-acetic acid methyl ester | HCID 70663184 | — |
Reaction Steps
The title compound was prepared in analogy to example 90, from [4-(4,5-difluoro-2-methoxy-phenyl)-pyridin-3-ylamino]-acetic acid methyl ester and 3-methanesulfonyl-5-trifluoromethyl-benzoic acid (example 114, intermediate a) and using a gradient of n-heptane:EtOAc (100:0 to 0:80) for the chromatographic purification. Colorless solid (30%). MS (ESI): m/z=559.096 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-796dea0268254995b0991fa5731ed1fe |
| Source note | uspto-grants-2015_03 |