HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4,5-Difluoro-2-methoxyphenyl)boronic acid → [4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-ylamino]-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4,5-Difluoro-2-methoxyphenyl)boronic acid | HCID 16217679 | — |
| Reactant | (4-Iodo-pyridin-3-ylamino)-acetic acid methyl ester | HCID 70663232 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | [4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-ylamino]-acetic acid methyl ester | HCID 70663491 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-ylamino)-acetic acid methyl ester and 4,5-difluoro-2-methoxyphenylboronic acid (CAS RN 870777-32-5) and using a gradient of n-heptane:EtOAc (100:0 to 0:100) for the chromatographic purification. Light yellow oil (82%). MS (ESI): m/z=309.104 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-3a3bac8c16a34568bdc6dba95f71feb3 |
| Source note | uspto-grants-2015_03 |