HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-(Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile → [2-(3-Methylamino-pyridin-4-yl)-phenyl]-acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-(Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile | HCID 3832884 | — |
| Reactant | N-[4-(4,5-Difluoro-2-methoxy-phenyl)-pyridin-3-yl]-N-(2-methanesulfonyl-ethyl)-2,6-bis-trifluoromethyl-isonicotinamide | HCID 86670771 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | [2-(3-Methylamino-pyridin-4-yl)-phenyl]-acetonitrile | HCID 70663360 | — |
Reaction Steps
The title compound was prepared in analogy to example 72, from (4-iodo-pyridin-3-yl)-methyl-amine (example 98, intermediate b) and [2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetonitrile (CAS RN 325141-71-7) after a reaction time of 6 days and using a gradient of n-heptane:EtOAc (100:0 to 20:80) for the chromatographic purification. Light yellow solid (69%). MS (ESI): m/z=224.118 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08987307B2 |
| Source dataset | uspto-grants-2015_03 |
| ORD ID | ord-e6effa0852f94d3ea35d9dcecc66d09b |
| Source note | uspto-grants-2015_03 |